Blar i forfatter "Trane, Ingmar"

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    • Molecular modeling study of the testosterone metabolizing enzyme UDP-glucuronosyltransferase 2B17 

      Trane, Ingmar; Sager, Georg; Dietrichs, Erik Sveberg; Ravna, Aina Westrheim (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-20)
      The dominant sex hormone testosterone is mainly metabolized by liver enzymes belonging to the uridine-diphospho (UDP) glucuronosyltransferase (UGT) family. These enzymes are the main phase II enzymes, and they have an important role in the detoxification of endogenous and exogenous compounds in humans. The aim of the present study was to improve the understanding of the binding properties of UGT2B17. ...

    • Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17 

      Trane, Ingmar (Master thesis; Mastergradsoppgave, 2018-05-25)
      The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...